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Introducing Product

Januprone is a topical solution, containing diphenylcyclopropenone or diphencyprone, a topical medicine for curing alopecia areata.

 

Alopecia areata (patchy baldness): is a sudden loss of hair in a circular pattern on the scalp with a well-defined region but not visible on the scalp. Alopecia areata is an autoimmune disease in which the lymphocytes around the hair follicle release chemical messengers, inhibiting hair growth for unknown reasons. It can affect the eyebrows, eyelashes, genitals and underarms, even the hair on the hands and feet, and is often resistant to treatment. These areas may be isolate or multiple. In rare cases, the entire hair loss may happen. There is no lesion, pain and itching on the area and the skin looks natural and smooth. Treatment for alopecia areata includes topical use and injection of corticosteroids, as well as chemical treatments such as topical solutions of diphenhydramine and dinitrochlorobenzene.

:Dosage Forms

Januprone topical solution in concentrations of 2%, 1.5%, 1%, 0.5%, 1.0%, 0.05%, 0.01%, 0.001%, 0.0001% is packaged in type 1 amber Borosilicate glass vials in single packs.

:Directions

 

The medicine should be taken under supervision of a physician. The percentage of januprone solution is determined by the attending physician for each patient; the immune response may be different with different percentages in different people.

 

A high dose of medicine for the first time is applied only in the medical office; according to the response observed by the Physician, more diluted doses are taken by the patient himself, but still under supervision of a physician. For taking lower doses of Januprone, flip the cap off the vial and use a syringe to withdraw enough amount of the solution, pour on a cotton swab, and apply to the lesion. Repeat it once a week. The solution should be left on the area for 6 to 24 hours and then washed. The area should be covered during treatment. Avoid contact with other parts of the body.

 

A satisfactory therapeutic response that is expected from Januprone is mild redness and itching that may last 24 to 48 hours. Let the redness and itching is relieved; then, apply Januprone every week. Januprone is usually used for several months until regrowth of all hairless areas is noticed.

 

Your physician should re-examine you one month after starting treatment. Your doctor will adjust the concentration of Januprone solution you are using according to your response to the previous concentration. In case of no response, your doctor may stop treatment. In case of successful treatment and hair regrowth, the doctor will change the concentration and frequency of applying medicine and/or discontinuing treatment.

:Product Mechanism

 

Januprone (diphenylcyclopropenone) solution stimulates skin cells. Such stimulation activates the immune system and the white blood cells get away from the hair follicle and move towards the stimulated area. Diphenylcyclopropenone does not work for all patients; however, reports reveal that more than 50% of people who have used it are satisfied with their hair regrowth.

Key points

  • This medication is only applied topically as advised by the physician.
  • The high concentrated solution (2%) should only be used at a medical office.
  • Taking diphenylcyclopropenone is prohibited during pregnancy and lactation; so, inform your doctor if you getting pregnant during treatment.
  • You may experience itching, burning sensation, blisters on your scalp and even something like a mild sunburn 1 to 2 days after your taking Januprone. Different people react differently; a few people will have mild redness and itching, while most may have very severe itching.
  • Consult your physician in case of very severe complications. In such case, treatment is stopped until the inflammatory reactions reduce.
  • In some patients, the lymph nodes in the back of the neck become aching; so, if such complications are observed, consult your doctor.
  • In some patients, the skin color in the areas tested by Diphen Cypron may turn to spotted light hues. If somebody else applies medicine for the patient, it is recommended to wear a mask and gloves.
  • Store refrigerated at 2 - 8 °C and protect from freezing.

Frequently Asked Questions

No. Janupron is a strong allergenic drug; do not use it without consulting a specialist doctor.

In order to start the treatment of diphencyprone drug, an initial sensitivity test is needed first. The purpose of this test is to observe the reactions of the immune system (including itching of the scalp, flaking of the head, redness, blisters, and complications similar to sunburn, etc.), which determines the result. For this reason, doctors usually use the highest percentage of the solution on a small area of skin (4 x 4 cm) of the arm or the damaged part of the head in the preliminary stage (sensitization).

It is recommended to use a cover during this period to prevent sunlight from coming into contact with the treated area. During the treatment, you should be careful not to touch the areas on which diphencyprone has been applied, and the doctor or the person applying the solution to the person’s head should wear gloves.

The percentage of Janupron solution is determined by the attending physician for each patient. The immune response in different people may be created with different percentages.

Doctors usually use the highest percentage of the solution, which is 2%, on a small area of the skin (4 x 4 cm) in the preliminary stage (sensitization). This 2% solution can be used on the lesion (damaged area) or on the arm.

After one to two weeks from the initial test, we enter the treatment phase, and in the first stage, the doctor uses the lowest percentage of the solution (0.0001%) in the parts that are empty of hair and checks the skin’s reaction. This work is done once a week, and 1 ml of the solution is enough in each session.

You should be re-examined by the doctor one month after starting the treatment. The doctor will readjust the concentration of the Januprone solution used according to your response to the previous concentration. If there is no response, the doctor may stop the treatment. In the event of successful treatment and hair regrowth, the doctor will change the concentration and frequency of use of the drug or stop the treatment completely.

The first side effects of diphencyprone are skin redness and itching that last for 24 to 48 hours after use. In some patients, swelling, itching, burning, blistering, etc. may be severe and even unbearable, in which case the doctor will order to stop the treatment.

The solution should remain on the scalp for 6 to 24 hours and then be washed, and it is recommended to use a cover during this time to prevent sunlight from hitting the head. The doctor will announce the duration of the medicine’s remaining on the scalp for other areas of hair loss.

Our recommendation is to store Janupron in the refrigerator at 2–8 degrees Celsius. Protect the medicine from sunlight and freezing. Storage at room temperature (less than 25 degrees Celsius) and for a short period of time (for example, up to two days) does not cause any problems. You can observe the stability of the solution by changing its color. Any color change indicates instability.

It should be used for up to one month and must be kept in the refrigerator.

In the case of eye contact, it leads to mild inflammation. After contact with the eyes, do not rub the eyes and immediately wash the eyes with plenty of water for at least 15 minutes. While washing, open and close your eyes several times to ensure sufficient washing. See a doctor if symptoms worsen.

If the medicine is swallowed by the patient, a large amount of water or milk should be fed to him immediately to dilute the amount of active ingredients. Then go to the hospital immediately. Do not induce vomiting in any way.

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